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What is NAD+?
Nicotinamide adenine Dinucleotide is an essential molecule that participates in energy exchanges and metabolism throughout our body. It is a building block of energy exchange in a healthy body and brain.
Why is NAD+ Important?
NAD+ levels decline with age as well as in stressful conditions such as depression, addiction, infections, and other medical illness. This results in poor neurological and physical functioning seen in aging. Replacement of NAD+ increases clarity of mind, focus, concentration, improved energy, elevated mood, decreased anxiety, and fewer cravings.
What does NAD + do in the Body?
NAD+ is used in the production of energy as an electron transporter in metabolism.
DNA Repair requires NAD+ to activate PARPs, which detect and repair damaged DNA.
Gene Expression: Sirtuins are NAD dependent enzymes that regulate gene expression, increase metabolism, extend cell life, and prevent neurodegeneration.
NAD+ also functions as a neurotransmitter for cell-to-cell communications in smooth muscle and brain cells.
NAD+ and NADH are used in alcohol metabolism and metabolism of lactate.
What is NAD Therapy?
High dose NAD + delivered IV bypasses the liver and digestive system and enters cells to increase gene expression and help repair DNA. Treatment lasts 3 to 8 hours per session and may require multiple sessions depending on the protocol and condition.
Conditions Treated by NAD+ Therapy:
- Substance Abuse
- Addiction – Alcoholism | Opioid Abuse Disorders
- Neurodegenerative Disorders | Anti-aging | Parkinson’s Disease
- Chronic fatigue
- Brain Fog
Benefits of NAD + Therapy:
- Increased Energy
- Improved Mood
- Increased mental clarity
- Increased focus and concentration
- Reduced cravings and addiction
More About NAD+
NAD+ is short for Nicotinamide Adenine Dinucleotide. NAD+ is an essential coenzyme in the body that regulates cellular energy metabolism and mitochondrial function. The mitochondria are the powerhouse of the cell where energy is made and regulated.
Mitochondrial health equals overall health and increasing NAD+ levels result in more efficient gene transcription, energy regulation, DNA repair, gene expression, and cell signaling. Improving NAD+ levels are now considered the pivotal process for improving cardiovascular health, weight management, anti-aging, cognitive function, and neuroprotection. NAD+ is the most important cellular co-factor for improvement of mitochondrial performance and energy.
Chronic illness and diseases of aging result in depression, worsened stress, loss of health-span, and hopelessness. NAD+ therapy has been shown to be capable of dramatically reducing symptoms of these illnesses by boosting the body’s natural cell repair. In addition to chronic illness, NAD+ has been used to treat chronic stress, depression, and anxiety.
Dr. Sinclair published a groundbreaking paper which found that increasing NAD+ levels in older mice made the mitochondria of a 2 years old mice resemble those of a 6-month-old mouse when evaluated for critical biochemical markers of muscle health. Similar results of improved markers of aging have been seen in humans infused with NAD+, in which mitochondria appear to be rejuvenated. Scientists have shown that mice fed a high fat diet and then had their levels of NAD+ increased gained 60% less weight than mice on the same high fat diet without the NAD+ levels increased.
As organisms age, their NAD+ levels decline. Dysfunctional cellular energy metabolism in mitochondria is increasingly implicated in diseases of aging, autoimmune disease, muscle wasting, neuropathies and other conditions. NAD+ therapy seems to reverse these conditions of aging by allowing Sirtuins to access DNA transcription and repair.
NAD+ has a favorable profile on enhanced mitochondrial functioning and protects against age related axonal degeneration. This may be part of the reason for the positive impact in the treatment of patients with Reflex Sympathetic Dystrophy, Parkinson’s Disease and Alzheimer’s Disease.
NAD drops dramatically with aging and replacement of NAD+ stores allows for better DNA repair and healthspan.
NAD can be boosted by oral supplementation to a degree, but directly by infusions. Elevating NAD allows for improvement in numerous processes including muscle repair and regeneration, nervous system protection, fertility, heart function, and fat metabolism .
NAD interacts with multiple systems in our body, providing muscle building, immunity, pancreatic functioning, cardiac protection, and multiple other impacts:
NAD Related Articles:
- NAD+ Brain Restoration for Addiction – The Fix – Addiction and Recovery, Straight Up. 24 September, 2015 – Norris, Paula
- Announcing the first Brain Restoration Summit: “NAD—The future of brain health” – Alchemy On Demand: Words Into Gold. September, 2015.
- Brain Restoration: ‘Too Good To Be True’ for Addiction and Disease? – The Fix – Addiction and Recovery, Straight Up. 20 March, 2014 – Morales, Royce Amy
- The NAD+ Deficiency Diseases – John P. Cleary, M.D.
- Diphosphopyridine Nucleotide in the Prevention, Diagnosis and Treatment of Drug Addiction – Paul O’Hollaren, MD
- Can NAD+ Slow the Aging Process? – Steve Spencer; Birmingham Medical News
- Critical step found in DNA repair, cellular aging
- UNRAVELING THE MYSTERIES OF AGING – Sinclair
- Rewinding the Clock – Sinclair
- Impairment of an Endothelial NAD+-H2S Signaling Network Is a Reversible Cause of Vascular Aging
- The Sinclair Lab
- Therapeutic Potential of NAD-Boosting Molecules: The In Vivo Evidence.
- Nicotinamide adenine dinucleotide homeostasis and signalling in heart disease
- Treating oxidative stress in heart failure: past, present and future.
- Skeletal muscle overexpression of nicotinamide phosphoribosyl transferase in mice coupled with voluntary exercise augments exercise endurance.
- NAD and Sirtuins Links
- Nicotinamide mononucleotide (NMN) supplementation ameliorates the impact of maternal obesity in mice: comparison with exercise.
- A conserved NAD+ binding pocket that regulates protein-protein interactions during aging.
- NAD⁺ in aging, metabolism, and neurodegeneration.
- Implications of altered NAD metabolism in metabolic disorders
- Role of Nicotinamide Adenine Dinucleotide and Related Precursors as Therapeutic Targets for Age-Related Degenerative Diseases
- Emerging therapeutic roles for NAD(+) metabolism in mitochondrial and age-related disorders
- Adipose tissue NAD+-homeostasis, sirtuins and poly(ADP-ribose) polymerases -important players in mitochondrial metabolism and metabolic health
- The Effect of Exercise on the Skin Content of the Reduced Form of NAD and Its Response to Transient Ischemia and Reperfusion in Highly Trained Athletes.
- The Roles of Mitochondrial SIRT4 in Cellular Metabolism.
- SIRT4 Is a Lysine Deacylase that Controls Leucine Metabolism and Insulin Secretion.
- SIRT4 and Its Roles in Energy and Redox Metabolism in Health, Disease and During Exercise.
- Effects of Chronic NAD Supplementation on Energy Metabolism and Diurnal Rhythm in Obese Mice
- NAD+ metabolism as a target for metabolic health
- Ketone-Based Metabolic Therapy: Is Increased NAD+ a Primary Mechanism
- NAD+ Regulates the Creation of Fat Cells